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By Charles F. Streckfus

This booklet studies the development made in salivary diagnostics up to now 20 years and identifies the most probably path of destiny endeavors. After an introductory part describing the histological and anatomical good points of the salivary glands and salivary functionality, salivary assortment units and diagnostic structures are reviewed. the sphere of “salivaomics” is then thought of intimately, protecting, for instance, proteomics, the peptidome, DNA and RNA research, biomarkers, and techniques for biomarker discovery. Salivary diagnostics for oral and systemic ailments are completely mentioned, and the function of salivary gland tissue engineering for destiny diagnostics is explored. The publication closes by way of contemplating felony matters and boundaries to salivary diagnostic improvement. Advances in Salivary Diagnostics could be an informative and stimulating reference for either practitioners and students.

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38. Naylor S. Biomarkers: current perspectives and future prospects. Expert Rev Mol Diagn. 2003;3:525–9. 29 39. Mayeux R. Biomarkers: potential uses and limitations. NeuroRx. 2004;1(2):182–8. 40. Biomarkers in risk assessment: validity and validation, environmental health criteria series, No. 222, WHO. co dlan=1&codcol=16&codcch=222 41. Perera FP, Weinstein IB. Molecular epidemiology: recent advances and future directions. Carcinogenesis. 2000;21:517–24. 42. Verbeek MM, De Jong D, Kremer HP. Brain-specific proteins in cerebrospinal fluid for the diagnosis of neurodegenerative diseases.

Insurance compa- 28 nies may deem saliva test results and diagnosis unacceptable for reimbursement purposes or to approve therapy and may insist on verifications with a “gold standard”—presumably serum. In litigation, questions also may arise regarding specific methods of collection. A method of collection must be consistent with preservation of the integrity of the specimen before tests. As an illustration, if the use of citrate to stimulate saliva flow could be proven to, even remotely, interfere with assayed substances, results of such tests may prove unreliable [4, 99].

Proteomics in neuropsychiatric disorders. Int J Neuropsychopharmacol. 2001;4:93–102. 45. Reiber H, Peter JB. Cerebrospinal fluid analysis: disease-related data patterns and evaluation programs. J Neurol Sci. 2001;184:101–22. 46. Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, Bloomfield CD, Lander ES. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science. 1999;286:531–7. 47. van Houten VM, Tabor MP, van den Brekel MW, Denkers F, Wishaupt RG, Kummer JA, Snow GB, Brakenhoff RH.

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